Bisphosphonates - chii? Bisphosphonates nokuti osteoporosis

Zvetsandanyama nemapfupa hurongwa anoita mumwe mukuru mashandiro ari mumuviri womunhu. Kuti vanotsigira zvose mitumbi. Bone utano inoita basa rinokosha. Kana paine matambudziko ari majoini, musana, kakawanda mitswe kuitika, kunaka upenyu hwomunhu yekudyidzana ipfupi. Mumwe chirwere chakadai izvo kunowanzoguma zviratidzo zvakadaro osteoporosis.

Kana nguva kuona chiremba, zvinokwanisika kuti yekudyidzana kuvandudza murwere ezvinhu. Pari, bisphosphonates yaishandiswa kurapa osteoporosis. zvinodhaka izvi zvinogona kupa tariro mushonga. Ngationei rudzii zvinodhaka.

Ndezvipi bisphosphonates

zita raro, boka iri zvinodhaka akagashira nokuda tigutsikane iri maumbirwo phosphonates maviri. The mashandiro chiito kwaibatsira nemhaka hombe zvakafanana ne pirofosfonatami kuti vane zvikuru muupenyu murau pamusoro karusiyamu tigutsikane mu mapfupa.

With yakafanana chimiro, bisphosphonates tunodzivisa makemikari kuti raigona kuraswa pirofosfonaty. Vanoita kuti vasunge karusiyamu ions uye avadzosere mafupa.

The zvakanaka divi negashiro zvinodhaka izvi ndechokuti mishonga ane bisphosphonates, vane chete nomugumisiro zvokusarudza pamusoro skeletal hurongwa, apo kuunganidza calcium.

Nokuda chiito ichi pakurapa osteoporosis zvinokwanisika kudzivirira kurasikirwa calcium phosphorus, ine kunobatsirawo kurapwa.

mhando bisphosphonates

Vakawanda vachiri handizivi pamusoro bisphosphonates. Chii? Zvinonzi zvino vakava rudzi chetatu boka iri zvinodhaka. Doctors kuramba kushandisa zvinodhaka, uye vokutanga zvizvarwa zviviri. Zvino zvinodhaka zvakawanda nekupedza ane bisphosphonates, vose vanogona kuva mapoka mapoka makuru maviri:

1. Simple kwete chine senitrogen.
2. Boka bisphosphonates, izvo zvinosanganisira senitrogen - aminobisphosphonates.
   

Musiyano pakati pemapoka maviri iri yokuti vane siyana anoita osteoclasts.

Nitrogen tubhokisi bisphosphonates

Chii? Mari idzi ayo sezvamunoita rine zvinotevera pakugadzira:

1. Ibandronatovaya asidhi ndohwaJehovha parudzi rwechitatu, synthesized achangobva kushandiswa chaizvo zvinobudirira nokuda kudzivirira osteoporosis vakadzi, kunyanya kuenda kumwedzi.
2. Zolendronovaya asidhi zvokusarudza anoita pfupa rinenge rine raidudzwa Anti-bundu maturo. Pahwaro iri pfuma anogadzirwa mishonga yakadai se "Zometa", "Zolendronat".
3. Alendronate yavaibvisa correctors chokuita isiri hormone muviri ari pfupa rinenge unokurudzira kwakakodzera paumbwe mapfupa mamiriro.
4. Ibandronate yavaibvisa pairi vabereke "Bonviva", "Boniva", "Bondronat" kuchititadzisa osteoclast basa, asi asingaiti kukanganisa nhamba yavo. bisphosphonates izvi nokuti Mabatirwo osteoporosis dzinobudirira, kunyanya sezvo prophylactic mumiririri vakadzi kuenda kumwedzi.
   

Ziva kuti iwe haufaniri kuzvidzora medicate, mishonga anofanira kupiwa nachiremba.

nyore bisphosphonates

Not rine senitrogen bisphosphonate zvinodhaka nokuda osteoporosis vari kushingaira kushandiswa. Idzi dzinosanganisira:

1. "Etidronate" muchimiro mahwendefa uye majekiseni. chinowanzoonekwa ushandiswe kwete chete osteoporosis, asiwo chirwere Paget vake, hypercalcemia, kunoitika pazuva pakanyorwa kenza.
2. "Clodronate" iri rakapa muchimiro capsules, mahwendefa uye mhinduro. Inoshanda osteoporosis uye osteolysis.
3. "Tiludronate" kazhinji ushandiswe chete vakuru vanotambura Paget chirwere. Vana, zvinonzi contraindicated.
   

Zvinofungidzirwa kuti mapoka aya maviri zvinodhaka vaine migumisiro pamusoro vanhurume muviri, saka vasikana dzakanaka vari nani akakodzera senitrogen tubhokisi mishonga. Chero zvazvingava, kusarudza kuita chiremba wako chete.

Efficacy mu nezvirwere zvakasiyana-siyana

Pane rose mazita zvirwere icho bisphosphonate mushonga kunogona kuva zvakwakanakira.

1. Osteoporosis.
2. Myeloma.
3. Deforming osteodystrophy.
4. Primary hyperparathyroidism.
5. Kutyora gadziriro mapfupa inotungamirwa.
6. Kana pfupa metastases.

Mumwe nomumwe izvi zvinhu chete chiremba prescribes mumwe mushonga, ayo chipimo chemushonga uye nguva yekushandiswa. Vaiita kuzvidzora kurapwa, anogona chete kukuvadza muviri.

mashandiro chiito

Sezvo bisphosphonates nokuti osteoporosis mishonga ndivo inonyanya kushandiswa, zvakakodzera elucidate kuti mashandiro avo chiito.

All masero mumuviri yedu yoku- nguva nenguva, zvakafanana chingataurwa pamusoro mafupa. Zvinonzi nekugadzirwa imwe pakuenzanisa osteoblasts, izvo basa kwetunhu zvinyama itsva, uye osteoclasts vane basa kuparadzwa kwayo. Saka, BF wachinjwa nechishamiso kuchidzivisa basa osteoclasts, uye mune zvimwe zviitiko kunyange kukonzera mashandiro yokuzvidzora kuparadzwa.

Zvinonzi panguva ino, masayendisiti kukwanisa zvizere edza kushandisa bisphosphonates nechigumbuso mapfupa kuparadzwa. Zvinonzi chete anozivikanwa kuti mishonga iyi inogona pamwe hydroxyapatite mu pfupa migove, nokudaro kuchinja vachikotama mafupa.

Unogonawo kuona kuti kana kushandiswa kwenguva refu, kuti kenza kurapa kwakavakirwa pfupi ichangopfuura bisphosphonates izvi yaishandiswa kurapa osteoporosis.

Bisphosphonates metastases

With kukura kenza kunouya mudariro apo masero kenza kuvhuna kubva chikuru bundu uye kupararira panyika muviri. Panzvimbo itsva zvavari kuda uye otanga kukura, zvichiumba metastases.

Pfupa rinenge kunoramba kuri akagadziridzwa, saka kunowedzera mukana wokuti utachiona hematogenous. Apo masero kenza kupinda mumwongo ivo kuvhiringidza chakaipa interplay pakati osteoclasts uye osteoblasts, iyo inotungamirira zvemamiriro kukura mapfupa tishu.

Sezvo kuona kuvapo metastasis kwakaoma, nokuti tanga, izvi kunoitika kushanda pasina zviratidzo, pamwe kenza unofanira kupfuura kwazvo kuongororwa kuziva foci yechipiri.

Pakati kurapwa zvose metastases Bisphosphonates anoshandiswa nevakawanda. zvinodhaka izvi zviri zvikuru nyore akashivirira nevarwere, ivo Kashoma vane marwadzo.

Vanogona kuva pamwe radiotherapy uye mishonga. Kana kushandisa zvinodhaka akadaro vaizivikanwa zvinoderedza kuitika mapfupa metastasis mune kenza yemazamu, uye vakawanda myeloma.

Kana anovandudza hypercalcemia iri rinenge zvakajairika panguva oncological zvirwere, zvinodhaka vane mugumisiro mukuru ari muchimiro majekiseni uye infusions. nemigumisiro Excellent vakaratidza nzira dzakadai se "Zolendronovaya asidhi", "Pamidronate". Mazuva Nechekare mashomanana pashure mharuro kurapwa nemiedzo vanoratidza normalizing ropa calcium, uye zvinogona kuramba kuti kusvika mazuva akawanda.

Dzinenge kurumbidza pakugamuchira bisphosphonates

Kana iwe usina kunzwa pamusoro bisphosphonates, chii, udza chiremba. Kubvuma mishonga iyi yaifanira maererano nemimwe mitemo:

• Unofanira kutora mushonga pashure chisinga-, awa mumwechete pamberi kudya.
• Geza pasi zvakawanda mvura inofanira kuva.
• Usashandisa zapivaniya dzimwe mvura, zvakadai muto, tii, kofi. Ivo kutadzisa Absorção de Água pamusoro bisphosphonates.
• Pashure kushandiswa mahwendefa haagoni pasi, zvinotora inenge hafu yeawa mu akarurama ainyatsokwanisa pave yegurokuro raiva shoma.
• Hazvina yakarumbidza chokubatanidza mabiko BF pamwe karusiyamu supplementation, magnesium, simbi uye aruminiyamu.

Kana ukatevera dzose dzave izvi, kuti bisphosphonate haazogumisi pasingadiwi nemishonga.

Bisphosphonates nokuti osteoporosis: zvayakanakira nezvayakaipira

In pakurapa inowanzoshandiswa bisphosphonates kuti osteoporosis. Mishonga anoshandiswa zvakafanana zvakanaka varume nevakadzi. The chikuru zvakanakira zvinodhaka izvi zvinogona kusanganisira:

• It harina mahormone.
• Regai kuita kuti pave zvemwoyo.
• Nyanyisa mapundu kushandisa BF kwete mberi.

Asi chero mafuta zvinogoneka nguva dzose kuwana nhunzi iri mafuta. Bisphosphonates, pasinei efficacy dzavo pakurapa osteoporosis, kuchiri kure wakakwana. Kunwisa entrainment kugamuchirwa anogona kupa zvinotevera marwadzo:

• Kukanganisa chiropa uye neitsvo.
• Kana achiita nomutsinga, zvingangoita kutanga hypocalcaemia.
• Zvingava yegurokuro kana mudumbu urikanwi.
• Pane rashes ari mumuviri.
• Mune dzimwe pane vakawanda simba, zvakawanda zvive, uye svoto.
• Kurwadziwa netsandanyama.
• Vision matambudziko.
• Manyoka kana manyoka.
  

Hatigoni kutaura kuti zvose izvi zvisingadiwi migumisiro vanofanira unooneka zvose murwere, asi iwe unofanira kuziva nezvazvo. Kana iwe uri Nachiremba bisphosphonates, chii, tsanangura kuti chiremba, yaachasarudza chete zvinodhaka chipimo chemushonga uye nguva kurapwa.

mishonga yakadaro nyanzvi pakurapa osteoporosis nezvimwe zvirwere. Usati kurongera mushonga, chiremba kunodiwa kuita kuongorora kuti azive mamiriro muviri ari pfupa uye calcium yakawanda homeostasis, saka regai wozviona kuti taurira zvinodhaka muboka iri.

, Unofanira kurarama mararamiro utano, kutevera mazano ose vanachiremba, mudye zvakanaka kudzivisa kuva kushandisa mishonga. Chete iyi, wako skeletal maitiro ichava yakanaka.