Anti-inonzi estrogen zvinodhaka: tsananguro, kushanda

Inonzi estrogen-blockers vane makemikari adzikatidza kuitwa inonzi estrogen. Antiestrogen nemishonga inoshandiswa mukurapa zvirwere zvakasiyana-siyana. Kushandiswa chaizvo pakurapa kenza pezvakaitwa yemazamu kutitadzise bundu kukura kana dziviriro wava kusvutazve. Sezvakaita nedzimwe zvinodhaka kuti anosangana mahormone mumuviri, mishonga iyi inofanira kushandiswa pasi zvokurapa achitarisirwa.

Kubatsira uye pokukuvadza ose inonzi estrogen

Estrogen, kana steroid kemikari synthesized zvikurukuru nokuda ovaries. Zvinokanganisawo wandei pezvakaitwa muviri. Women pazera mukubereka vana vane chepamusorosoro pamwero yepanyama kemikari. Zvisinei, An kunyanya mari, anogona kukonzera chirwere inozivikanwa hyperestrogenia. chirwere ichi kunogona kuita kuti kenza kwacho yemazamu uye endometrial kenza. Anti-inonzi estrogen zvinodhaka uye inonzi estrogen blockers uye aromatase FIs hakugoniwo kugadzira zvose. Zvisinei, mishonga iyi, uine uye kunaka ekushandiswa vakadzi nevarume.

Mhando inonzi estrogen-blockers uye kushandiswa kwawo

Kune akawanda-siyana inonzi estrogen-blockers. aromatase FIs chaizvoizvo kuvhara kugadzirwa inonzi estrogen. Kusarudza inonzi estrogen Kanotokonya modulators, akadai "Tamoxifen" "Clomiphene", yakagadzirirwa kuvhara inonzi estrogen receptors, uye vanoita zvakasiyana zvakasiyana siyana rejira. Antiestrogens uyewo kuvhara inonzi estrogen receptors.

Antiestrogens kutadzisa kutendeuka testosterone kuti estradiol uye inonzi estrogen mahormone kurega kushandisa kana kuvharidzirwa.

In kenza kurapwa, zvinodhaka izvi zvinoshandiswa kunetesa kukura anomera. Muchiitiko chino, sarudza inonzi estrogen Kanotokonya modulators zvinogona nangananga kusaruraude inonzi estrogen receptors. Blockers, kusanganisira "Clomiphene" Anonziwo dzimwe nguva inoshandiswa pakurapa mwana, vanogona kubatsira vamwe vakadzi vane zvinovanetsa ava nemimba. zvinodhaka izvi anoshandiswawo nevamwe vanachiremba pakurapa vana kunonoka kuyaruka kusvikira vakura zvakakwana.

Pakati muviri zvakaita kushandisa inonzi estrogen-blockers nokuda estrogenic mugumisiro mukuru wevakuru testosterone pamuviri. Testosterone ari aizotangira ane estrogen, aromatase FIs zvinogona kushandiswa kumisa paumbwe kwetsandanyama nekumwisa estrogen, kuramba munhu pasi pamwero mumuviri. Tsika iyi mwoyo vakawanda, kunyanya kana Anti-inonzi estrogen zvinodhaka kureva zvinangwa zvizorwa. Muchiitiko chino, vanhu vari kushandisa mapiritsi uye muviri zvokuwedzera pasina zvokurapa achitarisirwa.

nemishonga

Kune divi Migumisiro Anti-inonzi estrogen zvinodhaka. Vanogona kukonzera dzungu, kutemwa nomusoro, vangadikitira, kupiswa uye nokuvhiringidzika. endocrinologist chete vangasarudza yakakodzera chipimo chemushonga kuti murwere zvichienderana ezvinhu, uye zvinogamuchirika chikumbaridzozve nemishonga. The endocrinologist kunogona taurira dzose miedzo nokuda mahomoni ropa pakuongorora zvinonyatsorehwa utano murwere kuti asimbise kuti kushandisa Anti-estrogens isina yaishandiswa murwere.

varume kurapwa

With zera, mukono testosterone mumatunhu kushayiwa. Zvisinei, kana testosterone iri kukurumidza kana kwazvo akaderedzwa, zvinogona kutungamirira kukudziri- hypogonadism. mamiriro ichi kunoratidzwa muviri hatigoni kubereka kemikari ichi chinokosha, zvinogona kukonzera akasiyana-siyana zviratidzo, kusanganisira:

• kurasikirwa libido;
• rutapudzo okuwana uye unhu dzisingaoneki;
• erectile dysfunction;
• kuneta.

Kana isu kutaura estrogen, chinhu chokutanga vanhu vanofunga kuti ari munhukadzi kemikari, asi ayo kuvapo chendangariro kuti nhongo muviri ari kushanda zvakanaka. Kune mhando nhatu estrogens: estriol, estrone uye estradiol. Estradiol - Nde chimiro vanoshingaira inonzi estrogen nevanhu. It rinoita basa rinokosha kuramba mashandiro ngakuite mapfundo uropi. zvinodhaka Antiestrogen inokupai urume kuti akure zvakanaka.

Hormone kusaenzana - kukwidza padanho inonzi estrogen uye ungaderedza testosterone - zvinetso. inonzi estrogen yakawandisa ari munhurume muviri kungaita kuti:

• gynecomastia (kunyanya kukura chityu tishu);
• matambudziko zvemwoyo;
• mikana yakawanda nesitiroko;
• kufuta;
• Nezvinetso prostate.

Unogona kutora matanho akawanda kudzorera pakati nepakati padanho inonzi estrogen. Somuenzaniso, kana nekumwisa inonzi estrogen yako chokuita yakaderera kwevari testosterone, zvinogona kubatsira kuva testosterone yokutsiva kurapa pane inonzi estrogen blocker.

Pharmaceutical inonzi estrogen-blockers

Vamwe mishonga zvigadzirwa angabudisa inonzi estrogen-ichivharira kushanda nevanhu. Kazhinji, kazhinji vari chinangwa kushandiswa nevakadzi, asi kuwedzera mukukurumbira pakati pavanhu, kunyanya vaya vanoda kuva nevana. Testosterone zvokuwedzera kungatungamirira mbereko. Asi inonzi estrogen blockers akadai "Clomid" anogona kudzorera hormone Chiyero pasina zvinopesana kubereka.

zvinodhaka vanoverengeka vanozivikanwa se zvokusarudza inonzi estrogen Kanotokonya modulators, yemanyorero kutengeswa sezvo zvapanzvimbo kurapwa kenza yemazamu. Asi ivo rinogona kushandiswa kuvhara inonzi estrogen nevanhu. zvinodhaka izvi inoshandiswa dzakasiyana-siyana ezvinhu chokuita yakaderera testosterone, kusanganisira:

• kushaya mbereko;
• pasi dzisingaoneki count;
• gynecomastia;
• osteoporosis.

mishonga iyi inofanira kushandiswa zvokusarudza, zvichienderana murwere. Kushandisa zvakadai mishonga Anti-inonzi estrogen. At chemishonga unogona kutenga:

• "Tamoxifen".
• 'Arimidex'.
• "Letrozole."
• "Raloxifene".

Zvinoitika pfupa

Maererano vanachiremba, kwenguva refu kuona inonzi estrogen zvinodhaka kungaita endometrial kenza vakadzi. "Raloxifene" - a zvokusarudza inonzi estrogen Kanotokonya modulator - kunogona kudzivisa kukura kenza, zvokusarudza inoperera ari Absorção de Água ose inonzi estrogen. Zvisinei, mushonga uyu, ndiwo kugonawo zvichivhiringidza Migumisiro yakanaka inonzi estrogen pamusoro mapfupa arambe achirema. The mushonga - "lasofoxifene" - anogona kugadzirisa dambudziko iri. Rinovatadzisa kurasikirwa mapfupa arambe achirema vakadzi postmenopausal uye akazoita brittleness repfupa tishu. Kushandiswa kwezvinodhaka izvi kazhinji ngozi, asi kungawedzera ropa.

zvinodhaka kwavatori

Inonzi estrogen blocker "Tamoxifen" kunogona kubatsira kudzivirira kenza. Varwere kenza vanowanzoodzwa mwoyo, uye boka iri zvinodhaka anogona dyidzana zvakaipa pamwe mishonga, antidepressants. Vanofanira kushandisa "Paroxetine", nokuti kuti vakadzi kutora "Tamoxifen" uye "Paroxetine", shoma mukana rufu kupfuura vakadzi kutora "Tamoxifen" uye mumwe antidepressant. Izvi imhaka yokuti "Paroxetine" anoita zvokusarudza.

Antiestrogen yomuchipatara uye zvinodhaka

The disclosures vose mari izvi anoratidza kuti mumwe mushonga unoshandiswa nomumwe pane imwe nyaya.

"Clomid" kana "clomiphene citrate" aiva mumwe mishonga yepakutanga kushandiswa pakurapa gynecomastia, nokuti anomutsa pamwero rwokuzvarwa testosterone muviri. Pane zvimwe nemishonga kubva kwenguva refu kushandiswa, akadai chiratidzo matambudziko. Pane vanobudirira zvinhu pamusoro pamusika, izvo kuita saizvozvo asi "Clomid" ichiri hubudirire uye chipa kunovhengana chipi mutambi.

Ichi hachisi chinhu anabolic steroid, mumwe mushonga rinowanzogamuchirwa ushandiswe sechinhu chinoyamura vakadzi mwana, nokuti ane raidudzwa anokwanisa kukurudzira ovulation, izvo zvinoitwa ichivharira / kurerutsa zvinokonzerwa inonzi estrogen pamuviri. Kuva chaiwo, "Clomid" - kwemakemikari ehupfumi kuti chakaita zvokugadzirwa inonzi estrogen agonist / antagonist. Mune mamwe chipfuro nyama inogona kuvhara mano inonzi estrogen kusunga kune runoenzanirana Kanotokonya. Kushandiswa Its zvekuchipatara ndiko kukurira nyika akaipa inofambiswa ose inonzi estrogen ari hypothalamus-pituitary-ovarian hurongwa, iyo hunowedzera nokubudiswa LH uye FSH. izvi zvose zvinotungamirira ovulation.

Nokuti zvemitambo zvinangwa "clomiphene citrate" vakadzi vasina maturo. Zvisinei, varume, pane ichiwedzerwa pakuburitswa FSH uye (zvikurukuru) luteinizing kemikari kuti kunomutsa dzinongoitika testosterone. Izvi zvinonyanya kubatsira mutambi pakupedzisira munhu steroid kutenderera apo endogenous testosterone siyana vanonetseka. Pasina testosterone (kana zvimwe androgens), "Cortisol" Rinokura uye kunokanganisa mapuroteni usage mune tsandanyama. Asi iye nokukurumidza "Anodya" ruzhinji richangobva vawana tsandanyama pashure kukanzura. Clomid anogona kuita basa rinokosha mukudzivirira kukundikana ino kubudirira mitambo kunoguma. Vakadzi, zvakanakira kuita Clomid - Mano kudzora endogenous inonzi estrogen revarombo. Izvi zvichawedzera kurasikirwa mafuta uye tsandanyama, kunyanya munzvimbo dzakadai pazvidya uye magaro. "Clomiphene citrate" Zvisinei, kazhinji unobereka nemishonga vakadzi, asi, zvakadaro, kudiwa pakati boka iri vatambi.

"Tamoxifen" ichivharira inonzi estrogen receptors mumasero kenza yemazamu. Izvi chinomisa inonzi estrogen kubva kuwadzana navo uye kunoita kuti kukura uye weboka masero. Kunyange zvazvo "Tamoxifen" anoita somunhu antiestrogen ari mammary shwanu masero, izvozvo anoita sechinhu inonzi estrogen mune dzimwe nzvimbo dzomuviri: pfupa uye dumbu.

Women ne muyanzvi nechityu "Tamoxifen" invasive kenza anogona kushandiswa kwemakore 5-10 avhiyiwa, kuderedza mukana wokuti metastasis kufambiswa. It kunoderedza ngozi yokuva nekenza mune rimwe zamu. Nokuti mangwanani Danho rokugadzirira ichi rinoshandiswa kureva varwere vasingaiti kubereka. Aromatase FIs ndiwo nzvimbo kurapwa vakadzi kuenda kumwedzi.

"Tamoxifen" anogona kumisa kukura kana kunyange shure mapundu vari varwere metastatic kenza nevarwere. It rinogona kushandiswa yekuzvidzivirira dzichiri zamu onkologicheskihz pezvakaitwa.

mushonga uyu akatorwa nemuromo kazhinji muchimiro mahwendefa.

Nemigumisiro ine Anti-inonzi estrogen zvinodhaka zvinosanganisira kuneta, kupiswa, kusangana nekutsi kwemukadzi kuoma kana mvura uye chinja kwemanzwiro.

Vamwe vakadzi vane metastases mu pfupa rinenge zvingaitika marwadzo uye kuzvimba mune tsandanyama uye mapfupa. Izvi kazhinji hahugari refu, asi mune dzimwe zvisingawanzoitiki nguva vakadzi Angatanga dzakakwirira nhanho calcium muropa, iyo isina prokontroliruesh. Kana izvi zvaitika, ipapo kunokwanisa umbomiswa kwenguva yakati.

Rare, asi zvikuru nemishonga kunobvirawo. zvinodhaka izvi kungawedzera njodzi yokuva nekenza myometrium vakadzi vane kubereka. Inosimudzira kweropa ndiko kumwezve zvakakomba nemishonga. Deep tsinga thrombosis kunoitika, asi dzimwe nguva nhindi ropa clot anogona kutyora kure uye pakupedzisira adzikatidza tsinga mumapapu (pulmonary embolism).

Kashoma "Tamoxifen" kwaiva chikonzero kurohwa uye mwoyo kurwiswa vakadzi postmenopausal.

Zvichienderana kuenda kumwedzi mamiriro vakadzi "Tamoxifen" anogona kuva akasiyana zvinosuruvarisa pfupa. In vakadzi premenopausal, "Tamoxifen" anogona kukonzera rive dete mapfupa, asi vakadzi post-kuenda kumwedzi kunowedzera padanho calcium, zvakafanira kuti mapfupa simba.

Kubatsira zvinodhaka ichi kupfuura njodzi zvinenge zvose vakadzi kemikari-zvaanoda kenza yemazamu invasive.

Saizvozvowo, zvinodhaka riri "Toremifene", iro kubvumirwa kunorapwa kenza yemazamu metastatic. Zvisinei, mushonga uyu hakushande kana kushandiswa "Tamoxifen", asi pasina kushanda.

"Fulvestrant" ndiwo mushonga kuti inoperera yokutanga inonzi estrogen Kanotokonya, uye ipapo uyewo anobvisa Kanotokonya kubatanidzwa chinzvimbo. It anoita somunhu Anti-inonzi estrogen yose muviri.

"Fulvestrant" rinoshandiswa kurapa achimhanya kenza yemazamu metastatic, uye zvinowanzoshandiswa pashure zvimwe zvinodhaka hormone ( "Tamoxifen" uye aromatase FIs) iro akamira kushanda.

Common nemishonga zvingasanganisira kupiswa, usiku sweats, munyoro svoto uye kuneta. Tichingotarisa, unogona kuderedza mapfupa (osteoporosis), kana kutora nguva refu.

mushonga uyu akunda kuzivikanwa dzokushandisa vakadzi postmenopausal vasingadi kupindura "Tamoxifen" kana "Toremifene." dzimwe nguva rinoshandiswa kuti chinangwa chahwo vakadzi premenopausal, kazhinji akabatana ine luteinizing kemikari-kusunungura agonist kuti kudzima ovaries.

"Raloxifene" kushandiswa nevakadzi kuti kudzivirirwa uye kurapwa repfupa kurasikirwa kana osteoporosis pashure kubereka. Zvinobatsira kuramba mapfupa akasimba, kuderedza mukana mitswe.

"Raloxifene" uyewo vanogona kudzivisa panowanikwa kenza yemazamu invasive pashure kubereka. Iye haasi inonzi estrogen kemikari, asi anoita inonzi estrogen mune dzimwe nhengo dzomuviri, akadai mapfupa. Mune dzimwe nhengo dzomuviri (nebandauko dumbu), "Raloxifene" anoita somunhu inonzi estrogen blocker. Haana kuderedza zvakasiyana kuenda kumwedzi syndrome. Raloxifene chokuita boka zvinodhaka rinozivikanwa zvokusarudza inonzi estrogen Kanotokonya modulators-SERMs (estrogenic uye zvinodhaka antiestrogenic).

Anti-inonzi estrogen zvinodhaka uye Sports

Zvimwe zvinodhaka zvinonzi nevakawanda kushandiswa muviri kuvaka tsandanyama.

"Cyclofenil" - iri neanabolichesky / androgenic steroid. It anoita Anti-inonzi estrogen uye testosterone somunhu rinodhaka. "Cyclofenil" ndiwo simba chaizvo uye munyoro estrogen, asi anosunga inonzi estrogen receptors uye chinonditadzisa nokusungwa rwokuzvarwa inonzi estrogen receptors. Kutaura zvazviri, zvinoshanda zvakanaka kuti vamwe vatambi kutora mushonga munguva steroid kurapwa kuti tirambe yakaderera kwevari inonzi estrogen. The mugumisiro - kuderedza huwandu mvura mumuviri, hwakasikwa pamwe steroids uye zvinoderedza gynecomastia. The mutambi ane yakaoma panze, kushandisa zvinodhaka izvozvo, izvo Tingangonyanya kutorwa panguva kugadzirira makwikwi. Zvisinei, muviri, chishandisei shoma kazhinji nokuti vanosarudza pane inokwanisika 'Nolvadex' uye 'Proviron. "

Kufanana "Clomid", "Cyclofenil" riri basa vakadzi, sezvo ane kubatsirawo chete pagadzirwe mahormone muvarume. Kurera padanho testosterone kunokonzerwa zvinodhaka izvi hazvisi zvakakwana kutaura okunyanyisa kuvandudzika, asi achapa simba pfuma, kunyange chiduku kuwedzera uremu muviri, kuwedzera simba uye kuwedzera pakuberekwa kutsva zvinobvira. Zvabuda Ava kuoneka kunyanya yepamusoro vatambi vane zvishoma kana vasina ruzivo pamwe steroids. Shandisa migumisiro zvava kuonekwa chete pashure pavhiki.

Mune zvimwe zviitiko, vatambi vari kuona kwemakomo akadai mburwa, vakawedzera zvepabonde nemotokari uye inopisa flushes. Zviratidzo izvi zvinonyanya anoratidza hwokuti mukomboni zvechokwadi inobudirira. Pashure discontinuation dzimwe rakashuma akaora mwoyo uye zvishomanana kuderera simba. Avo vanotora mushonga somunhu Anti-inonzi estrogen panguva steroid kurapwa, anogona kuchengeta vanetsane kana kubata pomutumwa anomiswa.

"Proviron" ndiyo imwe mukuru anabolic androgenic steroids pamusoro pamusika. Pamutemo sevatsigiri "Mesterolone", zvazvinosarira zvikuru hazvina kutorwa nehama dzazvo pakati anabolic steroid vanoshandisa.

On kushanda hwaro Proviron ane mana makuru kushanda, izvo zvikurukuru kuona kwayo nezvaaiita. Chokutanga, ndiye mumwe simba kupfuura anabolic steroids, nokuti anowedzera uwandu achiparadzira vakasununguka testosterone, rinova kukosha anabolic pezvakaitwa muviri. Nzira iri nyore kuitarisa: kana uri kutora anabolic steroids, kuti tsandanyama gobvu kuwedzera.

"Proviron®" uyewo anokwanisa kutaura pamwe enzayemu aromatase, riri basa kutendeuka testosterone kuti inonzi estrogen. Nokusunga kuti aromatase, "Proviron®" anogona chaizvoizvo tunodzivisa kwayakaita, richipa kudzivirirwa nemigumisiro ose inonzi estrogen.

On "Mesterolone" anewo simba sungano nokuda androgen Kanotokonya. Izvi steroid anabolic usingabereki kudzvinyirira gonadotropins zvakafanana nohumwe anabolic steroids. Izvi zvinoita kuti tikwanise kuwedzera kugadzirwa dzisingaoneki uyewo androgens zvinodikanwa kuti kweiyi spermatogenesis. Izvi kwete chete kunowedzera nhamba dzisingaoneki, asi kunonatsiridza unhu kwayo.

Side Migumisiro "Proviron" hadzirishandisi gynecomastia kana zvakawandisa mvura. Izvi zvichaita yekudyidzana uyewo yekuzvidzivirira cheBP chokuita pakutora anabolic steroids. Kutaura zvazviri, "Proviron" rine Anti-estrogenic mugumisiro nokuda zvokurega kutendeuka testosterone kuti estrogen, kana kuderera izvi.

Mishonga-dzataurwa pamusoro apa havana kudzikisa inonzi estrogen pamwero asi sei muviri zvarwo.

Boka antiestrogenic mishonga zvinosanganisirawo agonists kwokusunungura zvinhu gonadotropic mahormone ( "Buserelin" uye ayo analogs), megestrol acetate ( "Megeys") "Parlodel" uye "Dostinex" anoshandiswa sezvo zvinodhaka, kumbomira prolactin secretion. Kushandiswa dzavo pakurapa dzisiri kodzera.

Mabatirwo kenza

Kuwedzera "Tamoxifen" The zvinotevera inonzi estrogen Kanotokonya blockers.

Three zvinodhaka kuti kurega inonzi estrogen kurimwa vakadzi postmenopausal, vave vakatenderwa kubata zvose mangwanani uye yemhando kenza yemazamu: "Letrozole" ( "Femara"), "Anastrozole" ( 'Arimidex') uye "Exemestane" ( "AROMASIN") .

The mashandiro chiito pamusoro Anti-inonzi estrogen zvinodhaka muboka iri - the ichivharira of enzayemu (aromatase) mu adipose rinenge riri basa shomanana inonzi estrogen mu post-kuenda kumwedzi vakadzi. Havazivi kukanganisa ovaries, saka chete inoshanda vaya vakadzi vane ovaries hadzishandi, kana nokuda kubereka kana nokuda kwechirwere luteinizing kemikari analoginen. zvinodhaka izvi vanobviswa zuva nezuva piritsi fomu. Vanoshanda zvakafanana zvakanaka pakurapa oncological pezvakaitwa ari pazamu uye yeprostate.

Dzimwe nguva kenza yemazamu kurapwa kunoda kurapwa ovarian. Izvi zvinogona kuitwa pamwe zvinodhaka analogues pamusoro luteinizing kemikari-kusunungura kemikari (LHRH) Somuenzaniso, "Goserelin" ( "Zoladex") kana "leuprolide" ( "Lyupron"). zvinodhaka izvi adzikatidza chiratidzo iyo richanayiswa kuti mumuviri ovaries kubereka inonzi estrogen navo. Vanogona kushandiswa chete kana ne "tamoxifen", aromatase FIs, "Fulvestrant" nokuti hormone kurapa vakadzi premenopausal.